Anti-endothelial cell antibodies are associated with peripheral arterial disease and markers of endothelial dysfunction and inflammation
نویسندگان
چکیده
منابع مشابه
The Relationship between Endothelial Dysfunction and Endothelial Cell Markers in Peripheral Arterial Disease
INTRODUCTION The endothelial function plays key roles in both promoting and protecting against atherosclerotic disease. Several methods, including peripheral arterial tonometry (PAT), have been reported to be useful for investigating endothelial dysfunction. Furthermore, the level of thrombomodulin (TM) is assumed to reflect the endothelial dysfunction. In the present study, we investigated end...
متن کاملEndothelial dysfunction and peripheral arterial disease.
We read with interest the study of Loffredo et al. investigating the association of oxi-dative stress and endothelial function in patients with peripheral arterial disease (PAD). The authors demonstrated that flow-mediated vasodilation (FMD) of the brachial artery was significantly lower in patients with PAD compared with controls, whereas 8-hydroxy-2-deoxy-2-deoxyguanosine (a marker of oxidati...
متن کاملRelationship between white blood cell count and circulating anti-endothelial cell antibodies detected in patients with peripheral arterial disease
Background and objectives: Circulating anti-endothelial cell antibodies (AECAs) are elevated in peripheral arterial disease (PAD) patients. In this context, these autoantibodies have been associated with the endothelial dysfunction and the pro-inflammatory status that surrounds atherosclerosis. On the other hand, white blood cell (WBC) count and inflammatory markers have been consistently assoc...
متن کاملEndothelial Dysfunction of Patients with Peripheral Arterial Disease Measured by Peripheral Arterial Tonometry
Objective. Endothelial dysfunction plays a key role in atherosclerotic disease. Several methods have been reported to be useful for evaluating the endothelial dysfunction, and we investigated the endothelial dysfunction in patients with peripheral arterial disease (PAD) using peripheral arterial tonometry (PAT) test in this study. Furthermore, we examined the factors significantly correlated wi...
متن کاملAnti-endothelial cell antibodies in Behçet's disease.
OBJECTIVE Circulating antibodies that bind to human endothelial cells cultured in vitro have been detected in a variety of diseases, including Behçet's disease. In this disorder the reported prevalence of AECA has varied widely. One likely source of variability is the ELISA assay itself, in which differing conditions and reagents have been used in different reports. METHODS We have re-examine...
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ژورنال
عنوان ژورنال: Interactive CardioVascular and Thoracic Surgery
سال: 2011
ISSN: 1569-9293
DOI: 10.1510/icvts.2011.275016